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By Julie Bienertova-vasku

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Archer, S. , et al. (2003), 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference', Sleep, 26 (4), 413-5. Arendt, J. (2012), 'Biological rhythms during residence in polar regions', Chronobiol. , 29 (4), 379-94. , et al. (2010), 'Circadian pattern of sleep, energy expenditure, and body temperature of young healthy men during the intermittent fasting of Ramadan', Appetite, 54 (2), 426-9. , et al. (2011), 'The effectiveness of a nondiet multidisciplinary weight reduction program for severe overweight patients with psychological comorbidities', J.

2006). Given the relevance of phase desynchrony in appetite regulation and food intake disorders, melatonin may be useful in the treatment of obesity. Exogenous melatonin has been shown to reduce food intake and weight gain in laboratory animals. However, since there are substantial differences between circadian regulation in laboratory rodents and humans, clinical trials are urgently needed in order to investigate the effects of melatonin on obese patients (Rastmanesh and de Bruin 2012). , 2005).

Specifically in mammals, REM and non-REM (NREM) sleep is associated with different brain electrical activity and provide EEG records with differing frequencies and wave amplitudes. Both also differ from the wakeful state. , in rats), NREM sleep may be divided into four stages, ranging from 1 (―shallowest‖, highest frequency) to 4 (―deepest‖, lowest frequency). , 2012b). REM, also called ―active sleep‖ or ―paradoxical sleep‖, is characterized by cortical activity, muscle hypotonia and rapid eye movements.

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